Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease
Cross-species dissection of causal pathologic triggers Our previously published AMP-AD meta-analysis of postmortem brain RNAseq defined 3,774 AD differentially expressed genes and implicated 30 human brain gene co-expression network modules, relying on an integrated clinical-pathologic diagnosis [2]. The modules were independently derived from seven brain regions and are organized into five overlapping consensus clusters (Supplementary … Read more