The global burden of mental and substance use disorders among adolescents and young adults

Blakemore SJ. Adolescence and mental health. Lancet. 2019;393:2030–1. Article  PubMed  Google Scholar  Degenhardt L, Stockings E, Patton G, Hall WD, Lynskey M. The increasing global health priority of substance use in young people. Lancet Psychiatry. 2016;3:251–64. Article  PubMed  Google Scholar  Patel V, Saxena S, Lund C, Thornicroft G, Baingana F, Bolton P, et al. The … Read more

Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease

Cross-species dissection of causal pathologic triggers Our previously published AMP-AD meta-analysis of postmortem brain RNAseq defined 3,774 AD differentially expressed genes and implicated 30 human brain gene co-expression network modules, relying on an integrated clinical-pathologic diagnosis [2]. The modules were independently derived from seven brain regions and are organized into five overlapping consensus clusters (Supplementary … Read more

Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases

Lee B, Wang Y, Carlson SA, Greenlund KJ, Lu H, Liu Y, et al. National, state-level, and county-level prevalence estimates of adults aged >/=18 years self-reporting a lifetime diagnosis of depression – United States, 2020. MMWR Morb Mortal Wkly Rep. 2023;72:644–50. Article  PubMed  PubMed Central  Google Scholar  Gaynes BN, Warden D, Trivedi MH, Wisniewski SR, … Read more

Circulating mitochondrial and cellular damage markers in long COVID: Links to cognitive function, psychological distress, and inflammation

World Health Organization. datadot. 2024 [cited 2024 Sept 9]. COVID-19 cases | WHO COVID-19 dashboard. Available from: https://data.who.int/dashboards/covid19/cases Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, De Jong AWM, et al. A molecular pore spans the double membrane of the coronavirus replication organelle. Science. 2020;369:1395–8. https://www.science.org/doi/10.1126/science.abd3629 Article  CAS  PubMed  PubMed Central  Google Scholar  … Read more

Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling

Weye N, Santomauro DF, Agerbo E, Christensen MK, Iburg KM, Momen NC, et al. Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark. Lancet Psychiatry. 2021;8:310–9. Article  PubMed  Google Scholar  Evensen S, Wisløff T, Lystad JU, Bull H, Ueland T, Falkum E. Prevalence, employment … Read more

Associations between mosaic loss and schizophrenia or bipolar disorder of young age

Robinson N, Bergen SE. Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions. Front Genet. 2021;12:686666. Article  PubMed  PubMed Central  Google Scholar  Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in … Read more