Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer. Researchers at The Jackson Laboratory (JAX) have created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development. Their findings, published recently in Nature Aging, provide a valuable open-access resource for the scientific community to explore aging and its role in increased cancer risk.
Rewriting the molecular story of aging cells
Using cutting-edge single-cell and spatial transcriptomics technologies, the researchers compared young virgin female mice to older mice and mapped how mammary gland cellular landscape changes over time. The team, co-led by Olga…