Introduction
First identified by Stevens and Johnson in 1922, SJS and TEN are now recognized as disorders with a continuum of severity, from milder forms (SJS) to the most severe (TEN). SJS/TEN is associated with multiple etiological factors, most notably drug-induced liver injury (DILI), making the identification of the responsible agent crucial for patient management. However, previous studies have lacked uniformity in diagnostic approaches, limiting the ability to draw clear conclusions about causality.
Epidemiology
The incidence of SJS/TEN varies across regions, with notable differences between studies. For instance, in Europe and the USA, the incidence of TEN is reported at about 1–2 cases per million people per year. However, studies from Asia are less comprehensive, with significant gaps in…