Summary: Researchers identified a rare genetic mutation in two schizophrenia patients that increased schizophrenia-related behaviors in mice. The mutation led to higher levels of glycine decarboxylase (GLDC), an enzyme that degrades glycine, reducing NMDA receptor activation.
Mice with extra copies of the GLDC gene exhibited schizophrenia-like behaviors, confirming its role in the condition. Advanced brain analysis showed that available glycine was significantly lower in a specific brain region, disrupting neural signaling.
Key Facts:
- Genetic Link: Extra copies of the GLDC gene led to schizophrenia-like behaviors in mice.
- Brain Disruption: The mutation lowered glycine availability in a key brain region, impairing NMDA receptor function.
- Neural Impact: Reduced synaptic activity and impaired learning-related brain functions…