Childhood ADHD medication shows protective effect against future psychosis

A major new study, led by scientists at University College Dublin and the University of Edinburgh and funded by the St John of God Research Foundation, has found that commonly prescribed attention deficit hyperactivity disorder (ADHD) medication in childhood may lower the long‑term risk of developing serious psychotic disorders, including schizophrenia. Treatment with methylphenidate, the … Read more

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling. The review, authored … Read more

Scientists call for integration of physical activity into psychiatric care

People with mental illnesses such as schizophrenia, depression or bipolar disorder die on average ten to 20 years earlier than the general population. The main causes of this are cardiovascular and metabolic diseases, which are triggered or exacerbated by a lack of exercise. Now, an international team of scientists led by MedUni Vienna is calling … Read more

Detecting major neurological disorders via saliva

A team of Korean researchers has, for the first time in the world, developed a technology capable of enabling early diagnosis of major neurological disorders, including epilepsy, Parkinson’s disease, and schizophrenia, using only a small amount of saliva. This study was conducted jointly by a research team led by Dr. Sung-Gyu Park of the Advanced … Read more

New research on two million people quantifies how genetic risks overlap across diagnoses

A sweeping new peer-reviewed study published in Genomic Psychiatry has introduced a concept that could reshape how psychiatrists and geneticists think about mental illness: genetic specificity. Led by Dr. Kenneth S. Kendler at Virginia Commonwealth University, the research team analyzed data from over two million individuals born in Sweden between 1950 and 1995, asking a … Read more

Study identifies brain region driving one-shot visual learning

Despite decades of research, the mechanisms behind fast flashes of insight that change how a person perceives their world, termed “one-shot learning,” have remained unknown. A mysterious type of one-shot learning is perceptual learning, in which seeing something once dramatically alters our ability to recognize it again. A new study, led by researchers at NYU … Read more

Study reveals rising psychosis rates among younger generations

People born more recently are being diagnosed with psychotic disorders (e.g., schizophrenia) more often and at younger ages than people born earlier, suggests a large study of more than 12 million people in Ontario, published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250926. “Individuals with psychotic disorders face substantial morbidity and risk of premature death, and often … Read more

Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling

Weye N, Santomauro DF, Agerbo E, Christensen MK, Iburg KM, Momen NC, et al. Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark. Lancet Psychiatry. 2021;8:310–9. Article  PubMed  Google Scholar  Evensen S, Wisløff T, Lystad JU, Bull H, Ueland T, Falkum E. Prevalence, employment … Read more

Improving survival in people with severe psychiatric disorders

An expert editorial suggests that widely used diabetes and obesity drugs may help close the long-standing mortality gap faced by people with serious mental illnesses by tackling cardiovascular risk and metabolic disease head-on. Editorial: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have potential to transform health outcomes for persons with bipolar disorder, schizophrenia, major depressive disorder … Read more