Genetic Mutation Linked to Schizophrenia Alters Brain Function
Summary: Researchers identified a rare genetic mutation in two schizophrenia patients that increased schizophrenia-related behaviors in mice. The mutation led to higher levels of glycine decarboxylase (GLDC), an enzyme that degrades glycine, reducing NMDA receptor activation. Mice with extra copies of the GLDC gene exhibited schizophrenia-like behaviors, confirming its role in the condition. Advanced brain … Read more