A research team led by Mount Sinai has uncovered mechanisms of abnormal immune cell function that may lead to Crohn’s disease, according to findings published in Science Immunology on March 21. The researchers said their discovery provides better understanding of disease development and could inform the development and design of new therapies to prevent inflammation before it starts in the chronic disorder.
Crohn’s disease is an inflammatory bowel disease (IBD) that causes chronic inflammation of the gastrointestinal (GI) tract, and symptoms can include abdominal pain, diarrhea, weight loss, anemia, and fatigue. Inflammation is the body’s natural response to infection or injury, but prolonged and untreated inflammation may cause damage to healthy cells, tissues, and organs. White blood cells in the GI…