Often diagnosed when surgery is no longer an option, pancreatic cancer is one of the most difficult cancers to treat and has one of the lowest rates of survival among major malignancies. Like many solid tumors, the most common type of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is shielded by the desmoplastic matrix-a dense barrier … Read more
Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). What makes our body turn against itself? Failure of the immune system to distinguish ‘self’ from ‘non-self’ entities leads to excessive autoimmune responses against self-proteins like myelin, which forms … Read more
Two Bengal tiger cubs born in Indonesia’s Bandung Zoo last year have died from a viral infection, a conservation official told AFP on Friday. The cubs, two males named Huru and Hara, were born last July to tigress Jelita, who remains in good health. According to the conservation agency of West Java province, the cubs … Read more
In a paradigm breaking study, Dr. Pavan Reddy, director of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine (BCM) and his team, in collaboration with Drs. Arul Chinnaiyan, S P Hicks Endowed Professor of Pathology, and Marcin Cieslik, assistant professor of pathology, both from University of Michigan Rogel Cancer Center, discovered … Read more
Neutrophil infiltration is a hallmark of pulmonary inflammation during respiratory viral infections, yet the origin of these cells has been a subject of debate. Using a golden hamster model of SARS-CoV-2 infection, the study led by Professor Xuetao Cao’s team at the Chinese Academy of Medical Sciences unveiled a dynamic spleen-to-lung neutrophil axis that operates … Read more
Newswise — Imagine a tiny superhero inside every cell of your body whose job is to stop damaged cells before they turn dangerous. That superhero is a gene called TP53, and for decades scientists have known it as the “guardian of the genome.” But what happens when the guardian breaks? A recent study led by Asst. Prof. Caner … Read more
Weeks, A. D. & Alfirevic, Z. Induction of labour: first, do no harm. Lancet 400, 1656–1657 (2022). Google Scholar Grobman, W. A. et al. Labor induction versus expectant management in low-risk nulliparous women. N. Engl. J. Med. 379, 513–523 (2018). Google Scholar Nicholson, J. M. et al. The association between the regular use of preventive … Read more
A long-running debate in vaccine design revolves around whether a vaccine should be optimized to prevent the virus from replicating inside an infected host or prevent the virus from transmitting to others. New research led by Penn State scientists suggests there may not have to be a tradeoff. The study in animal models, published today … Read more
A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more
Food allergies are serious and, for some, potentially deadly. And yet, despite decades of research into allergies and what causes them, very little is known about why the vast majority of people are able to tolerate foods that can sicken or even kill others. “We know a lot about what the immune system sees and does if … Read more