Background and objectives Terminal ileum intubation is considered the completion step of colonoscopy and is usually performed to assess the ileum. The histological examination of the ileal mucosa, which is acquired during terminal ileum intubation, may allow an accurate diagnosis. However, there is no absolute consensus on when ileoscopy and biopsy should be attempted. As … Read more
Current models of mortality risk after heart failure (HF) rely primarily on cardiac-specific clinical variables and may underestimate risk in elderly East Asian patients. Researchers from Japan used machine learning to analyze data from a nationwide registry of elderly HF patients. Their new model includes metrics of physical function and improved risk reclassification by about … Read more
Archyde The Hidden Risks of Everyday Relief: How Prolonged PPI Use Could Be Undermining Your Health For millions, medications like omeprazole, pantoprazole, and esomeprazole are a go-to solution for heartburn, acid… You can read the full story here: Omeprazole & Mineral Loss: Long-Term Use Risks. Source link
With congenital syphilis at a 30-year high in the US, experts stress that early and universal syphilis screening in pregnancy is vital to protect both mothers and newborns from preventable harm. Study: Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation Statement. Image Credit: Summit Art Creations / Shutterstock.com In a recent … Read more
Fanconi anemia is an aggressive, life-threatening disorder. Most individuals living with this rare genetic condition, characterized by bone marrow failure and cancer predisposition, survive into adulthood only with bone marrow transplantation and regular cancer screening. But a new study demonstrates that mutations in one particular gene in the Fanconi anemia pathway result in an even … Read more
Hydroxyurea remains effective long-term in reducing emergency department visits and hospital days for children living with sickle cell disease (SCD), according to new research published in Blood Advances. “This is one of the first large, real-world, long-term studies to assess the efficacy of hydroxyurea outside of a controlled setting,” said study author Paul George, MD, … Read more
Luiz Felipe de Paiva Lourenção, Federal University of San Paulo | Image Credit: Linkedin A recent cross-sectional study conducted in Brazil indicated that the interaction of inflammation and iron deficiency could be triggering a substantial amount of anemia cases in children. Iron deficiency anemia has long been known to lead to eventual degradation of cognitive … Read more
Anne de Wit, MD | Image Credit: Linkedin A recent prospective subanalysis of an international open-labeled trial indicated that early detection and prevention of preoperative anemia is possible before colorectal surgery. However, preoperative iron administration cannot completely prevent postoperative complications, including colorectal anastomotic leakage (CAL). “Despite evidence indicating that preoperative anemia is a significant predictor … Read more
A recent retrospective analysis study indicated a correlation between preoperative anemia and likelihood of postoperative delirium (POD) in elderly patients after non-cardiac surgery.1 POD is a serious complication that affects up to 5% of general surgery patients, depending on type of surgery and patient population. POD is also increased with longer hospital or ICU stays, … Read more
Apr 10 2025 Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent. Due to overlapping morphological, clinical, and immunophenotypic characteristics, distinguishing these disorders from related entities such as T-prolymphocytic … Read more