Dr. Vadim Jucaud’s lab at the Terasaki Institute has developed a vascularized liver tissueoid-on-a-chip (LToC) platform that recapitulates key structural, functional, and immunological features of human liver tissue, enabling the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
Liver transplantation remains the primary therapeutic option for patients with end-stage liver disease, yet progress in understanding transplant rejection and tissue regeneration has been limited by the lack of experimental models that accurately reflect human liver architecture and immune interactions. Conventional culture systems fail to capture the multicellular organization, vascular complexity, and dynamic immune responses that govern transplant outcomes,…