The National Institutes of Health has renewed support for Artificial Intelligence for Alzheimer’s Disease, or AI4AD. The new $12.6 million award to advance the project’s next phase, AI4AD2, brings its total investment in AI4AD to $30.7 million. Led by Paul M. Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) … Read more
A new study shows that APOE4 reshapes brain-linked immune and lymphatic pathways in strikingly different ways in females and males, with opposite cognitive effects when innate immunity is suppressed. Study: Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. Image Credit: ahmetmapush / Shutterstock In a recent study published in the journal Neuron, … Read more
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor protein called TIE2 as the missing link between two key signaling pathways that drive the growth of blood vessel abnormalities known as cerebral cavernous malformations (CCMs). The study, to be published March 27 in the Journal of … Read more
A new review links ultra-processed foods and their additives to higher cardiovascular risk, pointing to large human studies and inflammation-related mechanisms that may help explain why heavily processed diets can harm heart health. Key takeaways Higher intake of ultra-processed foods was associated with a higher risk of cardiovascular disease. Food additives may also contribute to … Read more
A new preclinical study shows that red blood cells can be tagged in vivo and used as long-lasting carriers for imaging agents and therapies, opening a new route for safer drug delivery and vascular imaging. Study: In vivo metabolic tagging and targeting of circulating red blood cells. Image Credit: The1969 Studio / Shutterstock In a … Read more
No matter the size or severity, wounds on human skin are difficult to monitor while they heal. Biopsies disrupt the wound site and are too invasive for routine, repeated monitoring, and most medical imaging devices that could do the job are large, expensive and booked up with more pressing diagnostics. Clinicians typically resort to visual … Read more
A clinical decision support tool that uses artificial intelligence (AI) to analyze scans after a stroke alongside treatment recommendations is associated with better quality care and long term outcomes for patients compared with usual care, finds a study from China published by The BMJ today. The researchers say the tool “offers a more efficient and scalable method … Read more
Measures of blood vessel health derived from routine blood pressure readings may help identify adults at increased risk for dementia, according to research being presented at the American College of Cardiology’s Annual Scientific Session (ACC.26). The findings from two studies that tracked patterns of arterial stiffness over time align with growing evidence that uncontrolled hypertension … Read more
Digital subtraction angiography remains the gold standard for diagnosing cerebrovascular diseases, including intracranial aneurysms, arteriovenous malformations, and arterial stenosis. However, the procedure requires operators to work under fluoroscopic guidance, resulting in prolonged exposure to ionizing radiation. To address this issue, vascular interventional robotic systems have been developed to allow operators to perform procedures remotely from … Read more
A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzheimer’s disease-related brain changes appear across racial and ethnic groups, underscoring the need for more inclusive approaches to studying and diagnosing the disease. … Read more