Iron Over Dopamine? Restless Legs Syndrome Guidelines Revamp

To reduce the risk for complications, the use of dopaminergic agonists in the treatment of severe restless legs syndrome (RLS) has become less common. RLS is characterized by an irresistible urge to move the legs, often accompanied by unpleasant sensations such as itching, tingling, or electric paresthesia, which typically affect the lower limbs. It affects … Read more

How to Freeze and Thaw Brain Tissue

Stories about humans waking up from cryosleep have dominated popular culture for decades in the Alien films, Cameron’s Avatar, and Nolan’s Interstellar. While these films are out there, space- and time-wise, we know the science exists offscreen. Globally, there are about 500 people in cryogenic preservation: 300 of them in the United States. Thousands more … Read more

How to Freeze and Thaw Brain Tissue

Stories about humans waking up from cryosleep have dominated popular culture for decades in the Alien films, Cameron’s Avatar, and Nolan’s Interstellar. While these films are out there, space- and time-wise, we know the science exists offscreen. Globally, there are about 500 people in cryogenic preservation: 300 of them in the United States. Thousands more … Read more

Novel Blood Test Could Help Diagnose, Track Alzheimer’s

A novel blood test that detects a key biomarker for Alzheimer’s disease (AD) could help physicians more accurately determine the presence and track disease progression. The test measures levels of the protein MTBR-tau243 — microtubule-binding region of tau containing the residue 243 — a biomarker of tau tangles in the brain that may be a … Read more

Gut Microbiome Influences Neurodegeneration

WASHINGTON, DC — Age-related neurodegenerative disorders — motor neuron diseases, demyelinating diseases, Alzheimer’s disease, and other proteinopathies — are at an “inflection point,” said researcher Andrea R. Merchak, PhD, with a fuller understanding of disease pathophysiology but an overall dearth of effective disease-modifying treatments. And this, Merchak said at the Gut Microbiota for Health (GMFH) … Read more