When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role. During periods of low energy-such as intermittent fasting or exercise-immune cells step in to regulate blood sugar levels, acting as the “postman” in a previously unknown three-way conversation between the nervous, immune and hormonal systems. These findings open up new approaches for managing conditions like diabetes, obesity, and cancer.
Rethinking the immune system
“For decades, immunology has been dominated by a focus on immunity and infection”, says Henrique Veiga-Fernandes, head of the Immunophysiology Lab at the Champalimaud Foundation. “But we’re starting to realise the immune system does a lot more than…