PSMA therapy may postpone hormone treatment in prostate cancer patients

Where previous research showed that PSMA therapy for prostate cancer can prolong the lives of patients who have exhausted all other treatment options, a new study now demonstrates that the therapy is also effective in an earlier stage of the disease. As a result, more burdensome hormone therapy can be postponed by twenty additional months, … Read more

Estradiol patches as effective as injections for locally advanced prostate cancer

Hormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) researchers. Men with cancer that has spread just outside the prostate are given hormone therapy to suppress levels of testosterone which … Read more

Replacing sedentary time improves insulin resistance in adolescents

Adolescents who replaced just half an hour of sedentary behaviors, such as sitting on the couch or spending time at the computer, each day for moderate-to-vigorous physical activity or sleep may lower their insulin resistance, a key factor in preventing the development of Type 2 diabetes, according to preliminary research presented at the American Heart … Read more

Menopause may raise women’s Alzheimer risk earlier than doctors once thought

A new review suggests the menopause transition may mark a critical window for Alzheimer’s prevention in women, shifting focus toward earlier detection, sex-specific risk factors, and more personalized care. Expert Review: Women’s midlife: the front line of Alzheimer prevention. Image Credit: izzuanroslan / Shutterstock In a recent review published in The Journal of Clinical Investigation, author … Read more

Early-life PFAS exposure may hinder adolescent bone development

Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may influence how children’s bones develop during adolescence, according to new research published in the Journal of the Endocrine Society. PFAS are synthetic chemicals found in water, food and everyday products. These “forever chemicals,” many of which persist in the environment and in the human body, may interfere with normal development, including bone growth. “Adolescence is a key period for … Read more

Stress hormones disrupt the internal GPS system of the brain

Persons under stress may have a harder time spatially orienting themselves. Researchers in Bochum have discovered why. The stress hormone cortisol disrupts the brain’s navigational system. It impairs the function of the grid cells that play a crucial role in orientation. This has been verified by researchers from Ruhr University Bochum, Germany, in an imaging … Read more

Father’s nicotine use may increase diabetes risk for offspring

A mouse study found that a father’s nicotine exposure can affect the offspring’s ability to process sugar and may contribute to diabetes risk, according to new research published in the Journal of the Endocrine Society. An estimated 40.1 million people in the United States have diabetes, according to the U.S. Centers for Disease Control and Prevention. Having diabetes … Read more

Blood test marker p-tau217 helps detect early dementia risk in cognitively healthy older women

A decades-long study of postmenopausal women shows that a simple blood biomarker may help identify individuals at higher risk of cognitive decline and dementia years before symptoms appear. Study: Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women. Image Credit: meeboonstudio / Shutterstock In a recent study published in JAMA Network … Read more

Hormonal imbalance and gut microbes linked to cognitive deficits in patients with PitNETs

Pituitary neuroendocrine tumors (PitNETs) are commonly associated with visual disturbances and endocrine abnormalities; however, many patients also experience cognitive deficits, particularly in memory, attention, and executive function, which significantly affect quality of life. Despite increasing recognition of this burden, the mechanisms underlying cognitive impairment remain unclear. Traditionally, cognitive changes have been attributed to tumor mass … Read more