Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process. Traditional methods, often relying on in vitro assays or manual manipulation of animal models, are both inefficient and unable to fully mimic in vivo conditions. Zebrafish, with their transparent bodies, rapid development, and genetic similarities to humans, are emerging as a powerful model for high-throughput screening. However, the existing phenotyping techniques are labor-intensive and rely on anesthesia, which can compromise physiological responses. These constraints make it clear that an automated, non-invasive system is necessary for efficient, accurate drug evaluation.
A team of researchers from Sun Yat-sen University has responded to this challenge with the development of the Automated…