in vitro

Dandelion leaves boost brain-protective compounds after digestion

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A common wild plant may hold hidden brain benefits. Dandelion leaf polyphenols survive digestion and continue targeting pathways associated with Alzheimer’s disease.  Study: Characterisation of Dandelion Polyphenols and Their In Vitro Neuroprotective Effects During Simulated Digestion. Image credit: DUSAN ZIDAR/Shutterstock.com A recent study in Foods examined the enzyme-targeted neuroprotective potential of polyphenols from dandelion flowers, roots, … Read more

Can camel milk improve health? Review highlights benefits but warns against drinking it raw

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From blood sugar control to immune and gut effects, camel milk is drawing scientific interest as a functional food, but this review says any promise must be weighed against the real safety risks of drinking it raw. Review: Camel Milk as a Functional Food: Nutritional Composition, Health-Promoting Benefits, and Safety Considerations. Image Credit: MehmetO / … Read more

“Bugs Delivering Drugs” – Researchers Publish New Approach To Colorectal Cancer Treatment Using Common Food-Borne Bacteria

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Baylor University researchers have published a novel approach to fight colorectal cancer, using modified bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. Michael S. VanNieuwenhze, PhD, FRSC, University Distinguished Professor and chair of the Department of Biology, along with Baylor doctoral students and a colleague at Texas Tech University Health Sciences … Read more

Comparing denture cleansers for effectiveness against Candida biofilms

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Background and objectives Candida species, particularly Candida albicans, are major contributors to denture-induced stomatitis because of their ability to form biofilms on removable dental prostheses. Although chemical cleansers are effective, concerns regarding material degradation and mucosal irritation have spurred interest in non-chemical alternatives. This review aims to systematically compare the efficacy of chemical and non-chemical denture cleansers … Read more

Targeted uterine mRNA treatment boosts fertility outcomes in mice

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Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine – which designs nanotechnology-based platforms for clinical translation across specialties – developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.  … Read more

Breakthrough soft robotics could redefine artificial heart technology

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A groundbreaking soft robotic heart could transform treatment for end-stage heart failure, bringing us closer than ever to fully functional, biocompatible artificial organs. Study: A soft robotic total artificial hybrid heart. Image credit: Africa Studio/Shutterstock.com Researchers developed a total artificial hybrid heart powered by soft robotics, which may open new horizons in heart failure and transplantation medicine. … Read more

Study links neurotensin deficiency to ovulatory dysfunction in PCOS

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Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations. Characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, PCOS affects 5% to 20% of women and stands as a leading cause of anovulatory infertility. The pathophysiology of PCOS involves abnormal … Read more

New automated system revolutionizes drug evaluation in zebrafish

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Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process. Traditional methods, often relying on in vitro assays or manual manipulation of animal models, are both inefficient and unable to fully mimic in vivo conditions. Zebrafish, with their transparent bodies, rapid development, and genetic similarities to humans, are emerging as … Read more

Exploring EGCG’s role in protecting against acetaminophen-induced liver injury

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Announcing a new publication for Acta Materia Medica journal. Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote. However, use of N-acetylcysteine is limited to the early stages of APAP-induced DILI and may cause adverse side effects. Consequently, it is imperative … Read more

Adrenomedullin’s role in Obesity-Linked insulin resistance

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A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more