Yuen, H. K. L. et al. A morphologic study of Fuchs dystrophy and bullous keratopathy. Cornea 24, 319–327 (2005). Google Scholar Hribek, A. et al. Fibrillar layer as a marker for areas of pronounced corneal endothelial cell loss in advanced Fuchs endothelial corneal dystrophy. Am. J. Ophthalmol. 222, 292–301 (2021). Google Scholar Weller, J. M., … Read more
Mice Unless noted otherwise, young female (8 weeks old) and male (4 weeks old) C57BL/6 mice were obtained from The Jackson Laboratory and old mice (18 months old) were acquired from the National Institute on Aging. For co-housing, mice were housed either two young + three old, or three young + two old per cage. Males were co-housed before … Read more
Sajedi, H. & Pardakhti, N. Age prediction based on brain MRI image: A survey. J. Med. Syst. 43, 279 (2019). Poloni, K. M. & Ferrari, R. J. A deep ensemble hippocampal CNN model for brain age Estimation applied to alzheimer’s diagnosis. Expert Syst. Appl. 195, 116622 (2022). Millar, P. R. et al. Predicting brain age … Read more
Credit: Cavan Images/Getty Some sex differences in brain-connectivity patterns become more pronounced with age, according to new research. Researchers studying brain-imaging data from people aged between 8 and 100 found that sex differences in the brain’s connections are minimal in early life, but then increase drastically at puberty; some of these differences continue to grow … Read more
Bar, A. et al. Pregnancy and postpartum dynamics revealed by millions of lab tests. Sci. Adv. 11, eadr7922 (2025). Google Scholar Mockridge, A. & Maclennan, K. Physiology of pregnancy. Anaesth. Intensive Care Med. 20, 397–401 (2019). Google Scholar López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding … Read more
GLP-1 receptor agonism counteracts omics aging in mice Nature GLP-1 Agonists as Therapeutics for Alzheimer’s Disease: Not Right Now, but Maybe in the Future Pharmacy Times GLP‑1s and Dementia: Sorting Hype from Hope in Brain Health Research Diabetes In Control Source link
Staphylococcus aureus bacteria (artificially coloured) were injected into mice to cause the severe condition called sepsis.Credit: Science Source/SPL Genes that protect the body against infection during youth can do harm in old age, according to a study1 in mice. The results hint that ageing lowers immunity in unexpected ways, not just by weakening the immune … Read more
HP can induce cells to undergo LDCD Mechanical force can be divided into two categories: mechanical positive pressure (PP) and hypobaric pressure (HP), due to positive and negative loading, respectively. We used mesenchymal stem cells (MSCs) as a cell source to study the mechanism of mechanical force-induced cell death. Surprisingly, HP treatment induced MSCs to … Read more
Her early research endeavours began during her medical studies, where she first explored the biology of ageing. “When I started at the age of 18 studying medicine, I started with research. At first, I looked at lung ageing, then I looked at immune ageing,” says Maier. It was during this time that seeking out the … Read more
Actor-turned-columnist Twinkle Khanna has invoked Bryan Johnson amid a spate of cases where women were arrested for murdering their husbands in India. In the latest edition of her column Mrs Funnybones, Twinkle agreed that marriage can be stifling so she listed ways of escaping it, routes far less tedious than murder and legal battle. The … Read more