Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids

Su, L.-J. et al. Delivery of mRNA for cancer therapy: progress and prospects. Nano Today 53, 102013 (2023). Article  CAS  Google Scholar  Huang, X. G. et al. The landscape of mRNA nanomedicine. Nat. Med. 28, 2273–2287 (2022). Article  CAS  PubMed  Google Scholar  Baden, L. R. et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. … Read more

Injury and therapy in a human spinal cord organoid

Hagen, E. M. Acute complications of spinal cord injuries. World J. Orthop. 6, 17–23 (2015). Article  PubMed  PubMed Central  Google Scholar  Sezer, N., Akkus, S. & Ugurlu, F. G. Chronic complications of spinal cord injury. World J. Orthop. 6, 24–33 (2015). Article  PubMed  PubMed Central  Google Scholar  Ahuja, C. S. et al. Traumatic spinal cord … Read more

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations

WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action (World Health Organization, 2022). Fisher, M. C. et al. Tackling the emerging threat of antifungal resistance to human health. Nat. Rev. Microbiol. 20, 557–571 (2022). Article  PubMed  PubMed Central  CAS  Google Scholar  Antibiotic Resistance Threats in the United States 2019 (CDC, 2019). … Read more

Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis

HP can induce cells to undergo LDCD Mechanical force can be divided into two categories: mechanical positive pressure (PP) and hypobaric pressure (HP), due to positive and negative loading, respectively. We used mesenchymal stem cells (MSCs) as a cell source to study the mechanism of mechanical force-induced cell death. Surprisingly, HP treatment induced MSCs to … Read more