Alpha-Ketoglutarate Enhances Adipose-Derived Stem Cells Survival in Wound Healing by Hypoxia-Inducible Factor 1-Alpha-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics
BACKGROUND Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to their multipotency, paracrine activity, and relative abundance. However, the clinical application of ADSC-based therapies is substantially limited by the harsh microenvironment of acute wounds, characterized by hypoxia, nutrient deprivation, and oxidative stress, which leads to massive apoptotic … Read more