Researchers have demonstrated a new class of low-cost, scalable sensors that can be used to monitor electrical activity in human cerebral organoids. Because electrical signals are key to understanding brain function, this advance facilitates research into both neurodevelopment and genetic disorders such as Angelman syndrome. Human cerebral organoids are millimeter-sized tissues comprised of cell types … Read more
The mother of a baby boy diagnosed with a rare blood condition a week before his first birthday is urging people to join the stem cell register in the hopes of curing her son. Ronnie, from Merseyside, had just started crawling when his mother Laura noticed he was bruising more. The one-year-old was eventually diagnosed … Read more
Pereira, F. A., Qiu, Y., Zhou, G., Tsai, M. J. & Tsai, S. Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 13(8), 1037–1049 (1999). Google Scholar Pereira, F. A., Qiu, Y., Tsai, M. J. & Tsai, S. Y. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): Expression during mouse … Read more
Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of later tumour growth, offering a new mechanistic link between chronic inflammatory disease and cancer risk. Study: Epigenetic memory of colitis promotes tumour growth. Image Credit: Antonio Marca / Shutterstock In a recent study published in the journal Nature, … Read more
A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more
Sildenafil – an active ingredient also marketed under the name of Viagra – improves symptoms in patients with Leigh syndrome. This has now been reported in the Cell journal by researchers at Charité – Universitätsmedizin Berlin, together with teams from Heinrich Heine University Düsseldorf (HHU), University Hospital Düsseldorf (UKD), and the Fraunhofer Institute for Translational Medicine … Read more
A multiomic atlas of the aging human hippocampus uncovers how epigenetic regulation of neural stem cells and immature neurons may shape cognitive decline or resilience in later life. Study: Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease. Image Credit: MP Art / Shutterstock In a recent study published in the journal Nature, researchers delineated neurogenesis … Read more
BACKGROUND Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to their multipotency, paracrine activity, and relative abundance. However, the clinical application of ADSC-based therapies is substantially limited by the harsh microenvironment of acute wounds, characterized by hypoxia, nutrient deprivation, and oxidative stress, which leads to massive apoptotic … Read more
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk of severe acute graft-versus-host disease (GVHD) following umbilical cord blood transplantation. The specific donor–recipient human leukocyte antigen mismatch triples the likelihood of life-threatening immune complications, and severe acute GVHD itself is associated with significantly worse survival. These … Read more
Parkinson’s disease is a progressive neurodegenerative disorder that affects more than one million people in the United States, with approximately 90,000 new cases diagnosed each year. Although available treatments can help manage symptoms, there is currently no cure or therapy proven to slow the progression of the disease. Parkinson’s disease is associated with reduced dopamine release in the brain. Dopamine is a … Read more