Orlando, Fla. — Fracture risk in people treated for obesity appears significantly lower with semaglutide (Wegovy) vs sleeve gastrectomy, new data suggest. Previous animal studies have suggested a dose-dependent effect of glucagon like peptide 1 (GLP-1) receptor agonists on trabecular bone, including increased osteoblast activity, reduced apoptosis, and suppressed osteoclast activity. However, human data have … Read more
TOPLINE: A substantial proportion of perimenopausal and menopausal women expressed willingness to undergo assessment for osteoporosis, especially among those of Chinese ethnicity and those with an older age, fracture history, and higher scores in perception of their osteoporosis risk. METHODOLOGY: Researchers conducted this cross-sectional study utilizing self-administered questionnaires to determine the factors that affect the … Read more
TOPLINE: Compared with a conventional ad libitum Mediterranean diet, an energy-restricted Mediterranean diet along with physical activity helped preserve bone mineral density (BMD) during weight loss in older women with metabolic syndrome, showing the most benefits at the lumbar level over a 3-year period. METHODOLOGY: Individuals with obesity and older adults exhibit increased vulnerability to … Read more
For many people, living longer brings health challenges: Osteoporosis, diabetes, Alzheimer’s disease. And of course, zombie cells. The technical term is senescent cells. They’re damaged and unable to repair themselves. They’re also more likely to linger in the body as we age — like zombies — secreting inflammatory molecules that can hasten our decline. “They … Read more
Women in early menopause treated with zoledronate in just two infusions, 5 years apart, show a significantly reduced risk of sustaining a vertebral fracture and better maintenance of bone mineral density (BMD) over a 10-year period than those receiving just one or no infusions over the period, suggesting the infrequent, early dosing to be a … Read more