Cell Line

New neural organoid system improves scalability and reproducibility for research

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Neural organoids have been heralded as having huge potential for advancing our knowledge of the brain in several fields. These include exploring the responses of brain tissue to drugs, investigating the effect of specific genetic mutations on neural electrical activity and characterising how neural systems develop.  In the past, viability of these systems has been limited by their scalability, reproducibility and longevity.  New research from King’s College London has succeeded in scaling up the organoid approach; … Read more

Optimized costimulatory domains boost tumor killing in CAR NK cells

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Researchers at the Ribeirão Preto Blood Center and the Center for Cell-Based Therapy (CTC) conducted a study using the NK-92 cell line to test new models of chimeric antigen receptors (CARs) with specific costimulatory domains, such as 2B4 and DAP12. The tests showed that these components helped make the cells “ready to attack,” thereby increasing their ability … Read more

AI and human scientists collaborate to discover new cancer drug combinations

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An ‘AI scientist’, working in collaboration with human scientists, has found that combinations of cheap and safe drugs – used to treat conditions such as high cholesterol and alcohol dependence – could also be effective at treating cancer, a promising new approach to drug discovery. The research team, led by the University of Cambridge, used … Read more

GSK3β identified as a driver of drug resistance in BRAF mutant melanoma

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A new research perspective was published in Oncotarget, Volume 16, on April 4, 2025, titled “GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells.” In this work, first author Diana Crisan and corresponding author Abhijit Basu from the University Hospital Ulm led a team that presents experimental evidence pointing to the protein … Read more