neuroleptic drugs

New Drug for Acute Schizophrenia Effective in Phase 2 Study

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LOS ANGELES — The novel phosphodiesterase 10A (PDE10A) inhibitor known as CPL’36 (Celon Pharma) is effective and generally safe in acute exacerbations of schizophrenia, new research suggested. In a phase 2 trial of 189 patients with acute schizophrenia, compared with the placebo group, the groups receiving CPL’36 20 or 40 mg once daily both met … Read more

Seasonality Linked to Different Bipolar Features

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LOS ANGELES — Mood episodes in patients with bipolar disorder (BD) that occur more frequently or severely during specific seasons — known as seasonality patterns — are associated with treatment response and different characteristics and subtypes of the disorder, new research suggested. In a study of more than 1700 patients with BD, investigators found links … Read more