Childhood ADHD medication shows protective effect against future psychosis

A major new study, led by scientists at University College Dublin and the University of Edinburgh and funded by the St John of God Research Foundation, has found that commonly prescribed attention deficit hyperactivity disorder (ADHD) medication in childhood may lower the long‑term risk of developing serious psychotic disorders, including schizophrenia. Treatment with methylphenidate, the … Read more

New digital shield against metabolic disease in youth psychosis

A new clinic-ready web-based risk prediction tool called PsyMetRiC is now available to forecast the risk of young people with psychosis developing cardiometabolic disorders such as obesity, metabolic syndrome and diabetes.  The algorithms behind PsyMetRiC have been specifically tailored for young people with psychosis, and predict clinically significant weight gain within one year, metabolic syndrome … Read more

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling. The review, authored … Read more

Study reveals rising psychosis rates among younger generations

People born more recently are being diagnosed with psychotic disorders (e.g., schizophrenia) more often and at younger ages than people born earlier, suggests a large study of more than 12 million people in Ontario, published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250926. “Individuals with psychotic disorders face substantial morbidity and risk of premature death, and often … Read more

Study isolates mania-specific genetic architecture in bipolar disorder

Researchers at King’s College London and the University of Florence have, for the first time, identified the specific genetic blueprint of mania, the defining feature of bipolar disorder. Bipolar disorder is one of the most severe and complex psychiatric conditions, affecting around 2% of people worldwide. While episodes of depression, psychosis and other symptoms are … Read more

Smoking cessation drug shows promise for treating cannabis use disorder

A new randomized controlled trial has found promising evidence that the smoking cessation medication varenicline (Chantix/Champix) can help people with cannabis use disorder (CUD) to reduce cannabis use. CUD is a rising problem globally, partly due to recent legalization in several countries and US states, and until now no medications have been found to treat … Read more

Postpartum Psychosis Risk Linked to Sister’s Medical History

LOS ANGELES — Risk for postpartum psychosis is significantly higher in women who have a sister who has experienced the condition and/or has bipolar disorder (BD), a new study showed. In a population-based cohort study of nearly 1.7 million women, those with a full sister who had had the disorder were 10 times more likely … Read more

Seasonality Linked to Different Bipolar Features

LOS ANGELES — Mood episodes in patients with bipolar disorder (BD) that occur more frequently or severely during specific seasons — known as seasonality patterns — are associated with treatment response and different characteristics and subtypes of the disorder, new research suggested. In a study of more than 1700 patients with BD, investigators found links … Read more

Delusions Often Appear Before Hallucinations in Early Psychosis

Summary: A new study has found that delusions typically emerge before hallucinations in individuals at high risk for psychosis, overturning a long-standing belief that hallucinations drive delusional thinking. By analyzing symptom progression across three large cohorts, researchers consistently observed that delusions were the earliest symptom, reappearing even before hallucinations during relapses. The study suggests that … Read more