Biomarkers

Predictive value of the reverse shock index multiplied by glasgow coma scale score for mortality in ICU heatstroke patients: a multicenter study

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Epstein, Y., Yanovich, R. & Heatstroke. N Engl. J. Med. 380, 2449–2459 (2019). Google Scholar  Dhainaut, J. F., Claessens, Y. E., Ginsburg, C. & Riou, B. Unprecedented heat-related deaths during the 2003 heat wave in Paris: consequences on emergency departments. Crit. Care Lond. Engl. 8, 1–2 (2004). Google Scholar  Shi, L. et al. Heatstroke: a … Read more

A prognostic nomogram for all frequencies sudden sensorineural hearing loss based on the commixed index of inflammatory–immune–hemostasis–nutrition

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Chandrasekhar, S. S. et al. Clinical practice guideline: Sudden hearing loss (Update). Otolaryngol. Head Neck Surg. 161(1_suppl), S1-s45 (2019). Google Scholar  Alexander, T. H. & Harris, J. P. Incidence of sudden sensorineural hearing loss. Otol. Neurotol. Off. Publ. Am. Otol. Soc. Am. Neurotol. Soc. Eur. Acad. Otol. Neurotol. 34(9), 1586–1589 (2013). Google Scholar  Byl, F. … Read more

The value of coagulation index in thromboelastography for predicting early pregnancy loss in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles

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Quenby, S. et al. Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. Lancet 397 (10285), 1658–1667 (2021). Google Scholar  Neill, S. Management of early pregnancy loss. JAMA 329 (16), 1399–1400 (2023). Google Scholar  Mumusoglu, S., Telek, S. B. & Ata, B. Preimplantation genetic testing for aneuploidy in unexplained recurrent pregnancy … Read more

How Fred Hutch scientists tackle world’s top infectious killer, TB

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But scientists are working toward better options. Shapiro was part of a committee that reviewed the evidence for a new TB tongue swab test, based on research from UW. Based on Shapiro and her colleagues’ recommendation, the WHO endorsed the approach earlier this month. The tongue swab test will help identify people with signs of … Read more

Siemens Healthineers Expands Brain Health Research Portfolio with New Blood-Based Tau Assays

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Siemens Healthineers has announced the availability of two new blood-based biomarker assays for research use: the Atellica IM Phosphorylated tau 217 (pTau217) and Atellica IM Brain Derived Tau (BDTau) assays. The launch marks an expansion of the company’s brain health research portfolio, with the tests designed to help scientists better understand neurological function and disease … Read more

A microbiota–host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction

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Weeks, A. D. & Alfirevic, Z. Induction of labour: first, do no harm. Lancet 400, 1656–1657 (2022). Google Scholar  Grobman, W. A. et al. Labor induction versus expectant management in low-risk nulliparous women. N. Engl. J. Med. 379, 513–523 (2018). Google Scholar  Nicholson, J. M. et al. The association between the regular use of preventive … Read more

Serum p-tau181 Levels in AL and ATTR Amyloidosis & Related Neuropathies

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Archyde Recent research has highlighted the potential of blood phosphorylated tau (p-tau) levels as biomarkers in diagnosing immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis. This advancement could enhance the clinical approach to these conditions, which are characterized by the abnormal accumulation of amyloid proteins that can lead to significant organ damage and dysfunction. The … Read more

A latent class analysis of cardiometabolic risk factors and the predicted prevalence of subclinical atherosclerosis in middle-aged Swedish adults

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Jebari-Benslaiman, S. et al. Pathophysiology of Atherosclerosis. Int. J. Mol. Sci. 23 https://doi.org/10.3390/ijms23063346 (2022). Bergstrom, G. et al. Prevalence of subclinical coronary Artery atherosclerosis in the general population. Circulation 144, 916–929. https://doi.org/10.1161/CIRCULATIONAHA.121.055340 (2021). Google Scholar  Lind, L. et al. Obesity is associated with coronary artery stenosis independently of metabolic risk factors: The population-based SCAPIS study. … Read more

Urinary 6-sulfatoxymelatonin as a predictive biomarker for brain injury in very preterm infants

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Rees, P. et al. Preterm Brain Injury and Neurodevelopmental Outcomes: A Meta-analysis. Pediatrics 150 (6), (2022). Google Scholar  Grunau, R. E. & Miller, S. P. Size and Location of Preterm Brain Injury and Associations With Neurodevelopmental Outcomes. Neurology 102 (8), e209264 (2024). Google Scholar  Joseph, T. T., Schuch, V., Hossack, D. J., Chakraborty, R. & … Read more

Molecular signatures of oocyte viability identified by follicular fluid proteomics

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World Health Organization. Infertility Prevalence Estimates. (2021). McGee, E. A. & Hsueh, A. J. W. Initial and cyclic recruitment of ovarian follicles. Endocr. Rev. 21, 200–214 (2000). Google Scholar  Hurwitz, A. & Adashi, E. Y. Ovarian follicular atresia as an apoptotic process: A paradigm for programmed cell death in endocrine tissues. Mol. Cell. Endocrinol. 84, … Read more