Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved in asbestos-induced carcinogenesis. The findings highlight both known and novel genes and pathways, providing valuable insights into the biological processes disrupted in exposed patients. This work contributes to ongoing efforts to define reliable diagnostic and prognostic biomarkers and lays the groundwork for future investigations and potential clinical applications in personalized approaches to MPM…