In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses. Lymph nodes are highly organized command centers of the immune system. Within these structures, immune cells … Read more
A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more
A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer … Read more
Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets for future precision medicine. Somatic genomics uncovers the outcomes of evolutionary competitions within our tissues, which can drive disease, counter monogenic disease, or protect from common diseases In a recent study published in the journal Cell, researchers reviewed … Read more
The continuous movement of the vocal cords weakens and eventually stops as laryngeal cancer progresses. Researchers have, for the first time, discovered that restoring cellular vibration reduces the aggressiveness of advanced vocal cord cancer. When cancer cells were exposed to sound-wave vibration, a protein that promotes cancer growth and severity decreased. “What music should we … Read more
A study published today in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilise the cancer genome. Unstable genomes are a fertile playground for cancer evolution, giving malignant cells more opportunities to grow, adapt and evade treatment. The researchers analyzed genome sequences from tumors with unusually high activity of LINE-1 … Read more
Cancer is one of the causes responsible for the most deaths worldwide; in 2020, for example, it resulted in ten million deaths. It has been estimated that micro-organism infections caused between 13-18% of these cases. Until now, the International Agency for Research on Cancer (IARC) has classified thirteen micro-organisms as carcinogenic, which include viruses, bacteria … Read more
A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the first time, in a study led by investigators at Weill Cornell Medicine and the New York Genome Center. The research, published Dec. 31 in Cancer Discovery, demonstrates a practical method for simultaneously measuring specific DNA mutations and … Read more
Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved … Read more
Each year, millions of women undergo mammography to screen for breast cancer, yet tiny calcium specks—known as microcalcifications—often evade detection or are misread, leading to delayed diagnoses or unnecessary biopsies. Conventional computer-aided tools rely on hand-crafted rules and struggle with the sheer variety of imaging devices and lesion patterns. In a recent study led by … Read more