Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) are advancing the understanding of a promising blood test that could personalize treatment and surveillance for patients with human papillomavirus (HPV)-associated throat cancer. The research, published in JAMA Otolaryngology – Head … Read more
A molecular test developed at UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine detected bile duct cancer at roughly twice the rate of standard pathology, offering clinicians a more accurate diagnostic tool for one of oncology’s more elusive malignancies. The test, called BiliSeq, was evaluated in a prospective, multi-institutional study published … Read more
In a paradigm breaking study, Dr. Pavan Reddy, director of the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine (BCM) and his team, in collaboration with Drs. Arul Chinnaiyan, S P Hicks Endowed Professor of Pathology, and Marcin Cieslik, assistant professor of pathology, both from University of Michigan Rogel Cancer Center, discovered … Read more
This article has been allocated 0.5 EA by the RACGP and ACRRM for the 2026-2028 triennium. You can self-report this CPD/PDP activity by logging it online with the RACGP and ACRRM. Click on the link for RACGP Quick Log or go to your ACRRM page. Leo is a 62-year-old aeroplane engineer who presents with a three-month history of … Read more
Further experiments determined that pTOS is a byproduct of the breakdown of tyrosine — an amino acid present in dietary protein — by bacteria in the gut. Treating the pythons with antibiotics prior to feeding abolished the eating-associated increase in pTOS levels. “We were able to work out a pathway in which pTOS is produced … Read more
As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction. There is currently no drug treatment available for this complication – eventually as fibrosis worsens, surgery becomes the only option. The researchers discovered that the biggest build up of … Read more
Artificial intelligence could make cancer diagnosis safer and fairer by learning when to defer to human pathologists without overloading them, according to researchers from the University of Surrey and Monash University. The approach tackles two critical problems that have limited the use of AI-assisted decision-making in cancer pathology, radiology and other fields where human expertise … Read more
A decades-long study of postmenopausal women shows that a simple blood biomarker may help identify individuals at higher risk of cognitive decline and dementia years before symptoms appear. Study: Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women. Image Credit: meeboonstudio / Shutterstock In a recent study published in JAMA Network … Read more
Scientists propose that Parkinson’s disease may begin far from the brain, where environmental toxins, microbiome disruption, and intestinal barrier damage interact to ignite the biological cascade leading to neurodegeneration. Environmental insults reduce gut resilience and initiate convergent mechanisms that drive Parkinson’s disease. A lifetime of environmental insults (including Western diets and food additives, nano- and microplastics, … Read more
Alzheimer’s-related brain changes progressed up to 20 times faster in women who also had abnormal levels of a Parkinson’s-related protein, according to a Mayo Clinic study published in JAMA Network Open. The same pattern was not observed in men. The findings suggest that when alpha-synuclein – a protein linked to Parkinson’s disease – accumulates alongside Alzheimer’s pathology, … Read more