Carcinogenesis

Polyploidy-induced senescence may influence aging and cancer risk

by

A new editorial was published in Volume 18 of Aging-US on February 8, 2026, titled “Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?” In this editorial, Iman M. Al-Naggar of the University of Connecticut School of Medicine, UConn Health, and the University of Connecticut Center on Aging, with George A. Kuchel of the University of Connecticut Center on Aging, examines the … Read more

Gene expression study reveals clues to asbestos-linked mesothelioma

by

Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved … Read more

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

by

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is well characterized, revealing key pathogenic genetic abnormalities that drive carcinogenesis (cancer development) and disease progression. Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein … Read more