The above-described methodology resulted in a multi-dimensional framework for a gNBS program consisting of 18 screening criteria (Table 1) assigned to two overarching categories and four subcategories: (A) Criteria that enable transparent disease selection: I. Four clinical criteria, II. Four diagnostic criteria, and III. Three therapeutic-interventional criteria … Source link
Antimicrobial resistance poses a growing global health crisis, with few new antibiotics in development. Researchers at Sultan Qaboos University have identified three novel antimicrobial peptides (AMPs) from dromedary camels that effectively target multidrug-resistant bacteria, offering potential alternatives to conventional drugs. Published in Frontiers in Immunology (Volume 17, 21 January 2026), the study combined bioinformatics predictions with experimental … Read more
Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors-a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain. … Read more
Bats, critical reservoirs of viruses with significant cross-species spillover risks, have long been understudied in the Indochina Peninsula. A study led by researchers from Beijing University of Chemical Technology, the Academy of Military Medical Sciences, and their partners has unveiled the region’s bat virome diversity, offering key insights into the origins of porcine epidemic diarrhea … Read more
As researchers unlock the diagnostic and therapeutic promise of the human microbiome, a new roadmap highlights the urgent need for standardization, better evidence, and clinician education to transform patient care. Perspective: The microbiome for clinicians. Image Credit: Kateryna Kon / Shutterstock A recent perspective published in the journal Cell outlines the challenges, opportunities, and necessary actions to … Read more
Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer. By analyzing public RNA-seq data through a comprehensive bioinformatics pipeline, scientists working with the Sbarro Health Research Organization (SHRO) have developed an in-depth view of the molecular mechanisms involved … Read more
A first-of-its-kind clinical trial clinical trial shows that therapeutic plasma exchange (TPE) combined with intravenous immunoglobin reduced biological age on average by 2.6 years, as measured by multi-omic biomarkers. Results of the single-blind, placebo-controlled trial are published in the May 28, 2025, issue of Aging Cell, providing early data on the impact of TPE on … Read more
Revolutionizing Soft Tissue Sarcoma Treatment with Functional Precision Medicine Soft tissue sarcomas (STS) represent a formidable challenge in oncology. A recent collaborative study involving leading research institutions and a biotech firm has unveiled a promising new strategy for improving treatment outcomes for these rare and aggressive cancers. The findings, published in npj Precision Oncology, highlight … Read more
A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled “Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).” Researchers from IVIRMA New Jersey, Yale School of Medicine, Yale University, and Acibadem Mehmet Ali Aydinlar University studied how a treatment called platelet-rich … Read more
Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study, published in Briefings in Bioinformatics on February 20 [10.1093/bib/bbaf054], highlights iDOMO’s ability to identify synergistic drug combinations using gene expression data, outperforming … Read more