Nearly all the world’s 10.6 million children experiencing serious health-related suffering (SHS) live in low- and middle-income countries with little to no access to palliative care specialized care for their illness, according to a comprehensive new report published in The Lancet Child & Adolescent Health. The study defines SHS as physical, psychological, social or spiritual … Read more
Novel non-Stimulant Shows Promise for Adult ADHD: Centanafadine Demonstrates Clinically Meaningful Enhancement Table of Contents Novel non-Stimulant Shows Promise for Adult ADHD: Centanafadine Demonstrates Clinically Meaningful Enhancement Centanafadine Shows Promise in ADHD Treatment: A New Approach to Symptom Management Understanding Centanafadine’s Impact on ADHD Symptoms Expanding the Research: Pediatric Trials Yield Positive Results safety Profile … Read more
LOS ANGELES — The novel norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) centanafadine (Otsuka Pharmaceutical Co., Ltd.) is effective and “clinically meaningful” for adult attention-deficit/hyperactivity disorder (ADHD), new research suggested. In a combined analysis of two phase 3 trials with a total of 859 adults, more patients who received the NDSRI had at least an … Read more
TOPLINE: Parental metabolic syndrome (MetS) had a notable impact on the metabolic health of offspring; paternal MetS showed stronger associations with several metabolic markers in boys, whereas maternal MetS was linked to elevated triglyceride levels in both sexes but affected other markers, primarily in boys. METHODOLOGY: Multiple studies have examined the influence of parental MetS … Read more
The second Lancet Commission on Adolescent Health and Wellbeing released its latest report, A call to action: the second Lancet Commission on adolescent health and wellbeing, on May 21 at a side event to the World Health Assembly in Geneva. The report argues that adolescent health is at a tipping point, with progress falling behind … Read more
Poor mental health, rising obesity rates, exposure to violence and climate change are among the key challenges facing our adolescents today, according to a global report. The landmark report, by experts in adolescent health including from Murdoch Children’s Research Institute (MCRI), has revealed how supporting young people’s health and wellbeing could improve economic, social and … Read more
TOPLINE: A recent study identified three clinically distinct vitiligo profiles on the basis of Vitiligo Patient Priority Outcomes (ViPPO) responses from real-world patient data. Classes with more severe emotional and social functioning impacts had more severe disease per physician assessment, visible areas of lesion involvement, and work productivity and quality-of-life (QoL) impairment. METHODOLOGY: Researchers collected … Read more
A new systematic review and network meta-analysis showed few differences in the cardiovascular (CV) effects of stimulants and noradrenaline reuptake inhibitors used to treat attention-deficit/hyperactivity disorder (ADHD). Short-term use of amphetamines, atomoxetine, lisdexamfetamine, methylphenidate, and viloxazine was associated with small increases in blood pressure (BP), pulse, or both in children, adolescents, and adults. Further, the … Read more
Illicit drug toxicity is an “escalating public health emergency” in Canada that significantly affects adolescents, yet pediatricians are ill prepared to manage it, new research suggested. A study of more than 1000 pediatricians in Canada who care for young people aged 12-18 years found that while close to 14% reported caring for at least one … Read more
TOPLINE: Janus kinase (JAK) inhibitors were associated with more infections, particularly herpes infections, in patients with atopic dermatitis (AD) compared with biologics, in a cohort study. METHODOLOGY: A prospective, multicenter observational study included 1793 patients (age, ≥ 12 years) with moderate to severe AD from the Dutch BioDay registry between October 2017 and July 2024. … Read more