Q: How would you summarize your study for a lay audience? Our study investigated the role of astrocytes, an abundant cell type in the brain, in regulating an immune response against glioblastoma (GBM)-a highly aggressive brain cancer. We found a subset of astrocytes that limits the immune response and can be targeted with therapeutics. Q: … Read more
Researchers at Washington University School of Medicine in St. Louis have upended decades-old dogma of how connections between brain cells are rearranged during states of heightened vigilance or attention. The team found that a brain chemical associated with alertness, attention and learning alters brain connectivity and function not by acting directly on neurons, the cells … Read more
Jin K, Yao Z, van Velthoven CTJ, Kaplan ES, Glattfelder K, Barlow ST, Boyer G, Carey D, Casper T, Chakka AB, et al: Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice. Nature. 2025 (https://doi.org/10.1038/s41586-024-08350-8. Online ahead of print). Liddelow SA, Olsen ML, Sofroniew MV. Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) … Read more