New mechanism driving glioblastoma growth offers potential treatment targets

Australian researchers have uncovered a critical mechanism driving the growth and spread of glioblastoma – one of the most aggressive and lethal forms of brain cancer – potentially paving the way for more effective treatments. In a new study led by Adelaide University scientists from the Centre for Cancer Biology (CCB), researchers identified a previously … Read more

Woman Suffered from What She Thought Were ‘Chronic Migraines.’ After a Visit to the Doctor, Everything Changed (Exclusive)

NEED TO KNOW A woman, who thought she was suffering from “chronic migraines,” ended up getting diagnosed with a more serious concern: glioblastoma “Getting my diagnosis was an interesting journey,” Becca Valle tells PEOPLE Glioblastoma is a type of brain cancer A woman thought she was suffering from “chronic migraines.” After seeking help, she soon … Read more

AI foundation model advances comprehensive brain MRI analysis

Mass General Brigham investigators have developed a robust new artificial intelligence (AI) foundation model that is capable of analyzing brain MRI datasets to perform numerous medical tasks, including identifying brain age, predicting dementia risk, detecting brain tumor mutations and predicting brain cancer survival. The tool. known as BrainIAC, outperformed other, more task-specific AI models and was especially efficient when limited training data were available. Results are published in Nature Neuroscience.  “BrainIAC has … Read more

Ride Cincinnati grant funds research on immune activating wafer for glioblastoma treatment

A multidisciplinary team of University of Cincinnati Cancer Center researchers has received a $40,000 Ride Cincinnati grant to study a delayed release preparation, or wafer, of an immunostimulatory molecule to stimulate the central nervous system (CNS) immune system after surgery to remove glioblastoma, a form of primary brain cancer. Jonathan Forbes, MD, the project’s principal … Read more

Why Abbey Barrett’s mum wants more federal government help funding brain cancer research

At the end of every day the Barrett family puts a colourful sticker on the lounge room wall. It’s a symbol they have survived another day without their precious daughter and sister Abbey who died of brain cancer 18 months ago. She was 11. Justine says that since losing Abbey the family “talk a lot … Read more

Targeting astrocytes could boost immunotherapy effectiveness in glioblastoma

Q: How would you summarize your study for a lay audience? Our study investigated the role of astrocytes, an abundant cell type in the brain, in regulating an immune response against glioblastoma (GBM)-a highly aggressive brain cancer. We found a subset of astrocytes that limits the immune response and can be targeted with therapeutics. Q: … Read more

What is glioblastoma, the aggressive brain cancer singer Michael Bolton was diagnosed with

Iconic singer and two-time Grammy-award winner, Michael Bolton, known for timeless hits like “When a Man Loves a Woman” and “How Am I Supposed to Live Without You?”, recently opened up on his battle with glioblastoma, a rare and aggressive form of brain cancer. Diagnosed in December 2023, the 72-year-old artist has since undergone multiple … Read more

New targeted therapy shows early success in treating pediatric high-grade gliomas

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma. They found that the drug, already FDA-approved for certain adult cancers, was generally safe and resulted in tumor reduction visible … Read more

Already approved drug avapritinib Shows Promise in Treating High-Grade Gliomas

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain barrier. Researchers from the University of Michigan, Dana Farber Cancer Institute and the Medical University of Vienna established a collaborative team to uncover a potential … Read more

Impact of Dexamethasone on Immune Response in Brain Cancer: New Study Reveals Long-Lasting Immunosuppression and the Need for Alternative Therapies

Dexamethasone and Brain Cancer: Understanding the Dual Effects Brain cancer presents some of the most daunting challenges in oncology, not only due to the malignancy itself but also… The post Impact of Dexamethasone on Immune Response in Brain Cancer: New Study Reveals Long-Lasting Immunosuppression and the Need for Alternative Therapies appeared first on NewsyList. Source … Read more