New research has yielded an updated definition of hyperfiltration to address age-related renal function decline in kidney donor candidates with obesity and glucose tolerance disorder.1 The revised formula uses both age and glomerular filtration rate (GFR) without body surface area correction to determine the threshold value for hyperfiltration, overcoming inherent limitations of the conventional method … Read more
Vikram Raghu, MD, MS Credit: Pitt Pediatrics New research is shedding light on the impact of inconsistent early immunosuppression practices on short-term outcomes following pediatric liver transplantation, with results suggesting centers with greater variability in induction type face higher rejection rates within the first year.1 Leveraging data from the United Network for Organ Sharing (UNOS) … Read more
Tuba Demirci Yildirim, MD, MSc Credit: ResearchGate Patients with rheumatic diseases who received biologic disease- modifying anti-rheumatic drugs (bDMARDs) after a kidney transplant had a high risk of serious infections, according to new research published in Clinical Rheumatology.1 “There is a significant knowledge gap regarding the adverse events associated with bDMARDs in rheumatic patients’ post-transplant, … Read more
Peery AF, Crockett SD, Murphy CC, Jensen ET, Kim HP, Egberg MD, et al. Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021. Gastroenterology. 2022;162:621–44. PubMed Google Scholar Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M. Genetics and pathophysiology of pancreatitis. Gastroenterology. 2019;156:1951-1968.e1. PubMed Google … Read more
Viyaasan Mahalingasivam, MPhil Credit: London School of Hygiene and Tropical Medicine New research is shining light on a significant association between severe COVID-19 infection and accelerated kidney function decline in hospitalized patients.1 Leveraging data from the Stockholm Creatinine Measurements (SCREAM) Project, the study found COVID-19 was associated with accelerated estimated glomerular filtration rate (eGFR) decline … Read more
A Lifeline Through the Stomach: PEG Tubes Offer Hope for Patients Struggling to Eat Millions of Americans face challenges getting the nutrition they need. Whether due to illness, injury, or swallowing difficulties, manny struggle to eat enough to stay healthy. For these individuals,a percutaneous endoscopic gastrostomy (PEG) tube can be a lifeline,providing a direct route … Read more
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49. Article PubMed Google Scholar Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Yang L, Venneti S, Nagrath … Read more
Fast, accurate diagnosis of multiple sclerosis (MS) can be life-changing for patients, and new updates to the existing criteria are aiming to make that possible, ensuring that those living with the condition get the treatment they need when it matters most. Building on decades of research and clinical experience, the McDonald diagnostic criteria have served … Read more
Antibiotics play a major role in bacterial infection treatment; however, their overuse disrupts commensal microbiota. Although probiotics can effectively alleviate antibiotic-associated diarrhea, they do not restore the gut microbiota to its pre-antibiotic state. In the future, more studies are required to understand whether any specific probiotic preparation could effectively restore gut microbiome diversity and composition … Read more