Advanced gastric cancer remains one of the deadliest malignancies, with a 5-year overall survival rate below 10%. In recent years, combining chemotherapy with PD-1 or PD-L1 inhibitors has become standard first-line care for previously untreated HER2-negative disease. Yet major global trials and subgroup analyses have pointed to a recurring pattern: Asian patients often experience stronger … Read more
Competing interests K.S. reports receiving personal fees for consulting and advisory roles from Bristol Myers Squibb,… The post Zolbetuximab & Nivolumab: Phase 2 Trial in CLDN18.2+ Gastric Cancer appeared first on Archynetys. Source link
IntroductionThe gut microbiome: a dynamic ecosystemMicrobial dysbiosis and CRCGastric cancer and Helicobacter pyloriMicrobial metabolites and host signalingHost immune response and tumor microenvironmentClinical implications and future directionsReferencesFurther reading This article explains how host–microbiome interactions contribute to gastrointestinal cancer risk through microbial genotoxins, metabolic signaling pathways, immune dysregulation, and tumor microenvironment remodeling in colorectal and gastric cancers. … Read more
Gastric cancer remains the fifth leading cause of cancer-related deaths worldwide. Although its overall incidence has declined, early-onset cases—diagnosed before age 50—display unique biological and clinical patterns. These include diffuse histologic features, signet ring cell predominance, and poor prognosis. Environmental and lifestyle exposures, such as Helicobacter pylori infection, smoking, and high-salt diets, are known contributors. … Read more
Rates of certain cancers in the United States — including breast, colorectal, and thyroid cancers — increased between 2010 and 2019 among patients aged less than 50 years, while overall cancer incidence and mortality rates did not increase, a new study found. Among the more than two million cases of early-onset cancer diagnosed during this … Read more
Helicobacter pylori (H. pylori) is a widespread bacterial infection associated with gastritis, peptic ulcers, and gastric cancer. While conventional antibiotic-based treatments have been the gold standard for eradication, their efficacy has been steadily declining due to the alarming rise in antibiotic resistance. This has spurred interest in alternative therapies, one of which is fecal microbiota transplantation … Read more
Cancer statistics in Europe are encouraging: Between 1989 and 2025, nearly 7 million deaths were averted in the European Union (EU), including over 373,000 from breast cancer. This finding emerged from a study recently published in the Annals of Oncology by a team of researchers led by Carlo La Vecchia from the University of Milan … Read more
Are you aware that your blood type could be linked too your risk of developing stomach cancer? This article dives into the surprising connection between blood type A and increased stomach cancer risk, exploring the latest research and potential explanations. Learn more about how your blood type might affect your health and what steps you … Read more
A team of Singapore scientists has made a significant discovery in understanding stomach cancer, a disease that remains one of the deadliest cancers worldwide. By using advanced mapping technologies, they created a detailed “atlas” of stomach tumors, revealing hidden patterns in how cancer cells behave, evolve and interact with their environment. These insights could lead … Read more
The American College of Gastroenterology (ACG) has issued its first clinical practice guideline on the diagnosis and management of gastric premalignant conditions (GPMCs) including atrophic gastritis, gastric intestinal metaplasia, dysplasia, and certain gastric epithelial polyps, all of which have an increased risk of progressing to gastric cancer. The guideline was published online on March 12 … Read more