TOPLINE: A meta-analysis of randomized controlled trials involving over 59,000 patients with diabetes or obesity showed no statistically significant difference in the risk for suicide between those treated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and placebo. METHODOLOGY: Initial reports of increased suicidality in GLP-1 RA users compared with the general population raised concerns … Read more
The advancement of digital tools has brought about a profound transformation across many sectors, and healthcare is no exception. When used with the appropriate ethical and technical safeguards, these tools can contribute to increased productivity and career development. In recent years, several studies have highlighted the potential benefits of digital technologies for healthcare professionals. One … Read more
TOPLINE: A dry suction technique was noninferior to a wet suction technique for endoscopic ultrasound–guided fine-needle biopsy (EUS-FNB) in patients with solid pancreatic lesions, with comparable diagnostic accuracies. A single needle pass achieved more than 90% accuracy in both the techniques. METHODOLOGY: This randomized noninferiority trial conducted across four hospitals in China (2022-2024) assessed the … Read more
The possibility of type 2 diabetes (T2D) remission has been widely debated in recent years, primarily due to studies investigating the effects of calorie restriction and weight loss on glycemic control. However, experts warn that achieving normal blood glucose and glycated hemoglobin levels does not necessarily mean disease reversal. “At the time of diagnosis, approximately … Read more
For many people, living longer brings health challenges: Osteoporosis, diabetes, Alzheimer’s disease. And of course, zombie cells. The technical term is senescent cells. They’re damaged and unable to repair themselves. They’re also more likely to linger in the body as we age — like zombies — secreting inflammatory molecules that can hasten our decline. “They … Read more
TOPLINE: Four serum neurofilament light chain (NfL) tests showed high accuracy in diagnosing and predicting progression of amyotrophic lateral sclerosis (ALS) in a new study. Investigators said the findings also offer diagnostic and prognostic cutoff values and lay the foundation for future use of the tests in clinical practice. METHODOLOGY: This study included 139 patients … Read more
TOPLINE: Dolutegravir plus lamivudine demonstrates noninferiority to the standard-of-care three-drug regimen in treatment-naive patients with HIV without preliminary drug resistance testing. METHODOLOGY: Researchers conducted a randomized, noninferiority, phase 4 trial to evaluate the efficacy and safety of dolutegravir plus lamivudine in untreated patients with HIV with no preliminary drug resistance testing. Overall, 223 participants (median … Read more
TOPLINE: National rates of uterine rupture in trial of labor after cesarean (TOLAC) increased from 0.20% in 2010 to 0.37% in 2022, with an annual percentage increase of 6.2%. Among 1,016,073 deliveries analyzed, 2888 uterine ruptures occurred, representing 0.28% of cases. METHODOLOGY: Researchers conducted a repeated cross-sectional analysis using natality files from the National Vital … Read more
The National Institute for Health and Care Excellence (NICE) has recommended cladribine (Mavenclad, Merck Serono) for adults in England with relapsing-remitting multiple sclerosis (RRMS). This decision makes the NHS the first healthcare system in Europe to widely offer the at-home tablet for patients with active MS. The final draft guidance means cladribine is an option for … Read more
TOPLINE: The occurrence of acute brain lesions was lower with a transseptal puncture than with a conventional retrograde aortic approach in patients undergoing left ventricular catheter ablation, with no significant difference in the safety or efficacy profile between both approaches. METHODOLOGY: Previous studies suggested that catheter ablation for atrial fibrillation results in new brain lesions … Read more