Blood markers offer hope for early detection of teen depression

Using a novel lab method they developed, McGill University researchers have identified nine molecules in the blood that were elevated in teens diagnosed with depression. These molecules also predicted how symptoms might progress over time. The findings of the clinical study could pave the way for earlier detection, before symptoms worsen and become hard to treat. … Read more

Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions | Infectious Diseases of Poverty

Translation of mRNA vaccines in APCs is an initial step to elicit immunity An mRNA vaccine delivers a genetic “instruction manual” (mRNA) that teaches cells to translate a harmless piece of the target pathogen (i.e., antigen). Specialized cells called APCs—the body’s “intelligence agents”—swallow the vaccine particles. These APCs perform three critical tasks: (1) capture: swallow … Read more

Understanding the mechanisms behind alcohol-associated liver disease

A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition. ALD, caused by excessive alcohol consumption, remains a significant contributor to liver-related mortality worldwide. Effective treatments are still limited, underscoring the need for a deeper understanding of its … Read more