A sweeping new review shows how disruptions in the gut microbiome may fuel obesity, insulin resistance, and cardiovascular risk, while pointing to diet and other microbiome-focused strategies that could help restore metabolic balance. Integrative mechanistic framework linking gut dysbiosis to systemic metabolic dysfunction. Arrows indicate the progression of events from exogenous and host-related factors to … Read more
Despite advances in the field of organ transplantation, long-term organ rejection that can become apparent a decade or more after a heart or lung transplant remains a common problem for patients. This chronic organ failure has long been attributed exclusively to the recipient’s immune system attacking the foreign organ over time. Now, a study led … Read more
Emerging evidence suggests widely used metabolic drugs could influence brain aging pathways, yet large clinical trials are still needed to confirm whether they truly alter the course of neurodegenerative disease. Study: The promise of GLP-1 receptor agonists for neurodegenerative diseases. Image Credit: Antonio Marca / Shutterstock In a recent review published in the Journal of Clinical … Read more
Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise. Introduction … Read more
New research uncovers how heavy smoking rapidly disrupts blood and airway biology, revealing the hidden damage that accelerates disease risk in otherwise healthy adults. Study: The effects of heavy smoking on oxidative stress, inflammatory biomarkers, vascular dysfunction, and hematological indices. Image Credit: CGN089 / Shutterstock In a recent study in the journal Scientific Reports, researchers comprehensively evaluated … Read more
New research reveals that it’s not just the amount, but the oxidative power of air pollution that shifts key immune signals in expectant mothers, potentially impacting both maternal defenses and fetal development. Study: Personal exposure to air pollutants and immune system biomarkers in pregnant women. Image Credit: chayanuphol / Shutterstock In a recent study published in the … Read more
Acute coronary syndrome (ACS) in patients with SARS-CoV-2 infection represents a critical intersection of viral-induced inflammation and cardiovascular pathology. This review explores the dual mechanisms driving SARS-CoV-2-associated ACS and evaluates emerging therapeutic strategies, including phytomedicine and nanotechnology, to address both viral and cardiovascular complications. SARS-CoV-2 and ACS pathogenesis SARS-CoV-2 infection exacerbates ACS through systemic inflammation, … Read more
A team of researchers from the Rice Biotech Launch Pad at Rice University has developed an implantable “cytokine factory” that safely triggers potent immune responses against hard-to-treat cancers, including metastatic melanoma, pancreatic and colorectal tumors. The study, published in The Journal of ImmunoTherapy of Cancer, details how an immunoprotected device near the tumor microenvironment containing cells … Read more
From babyhood to adulthood, the bacteria and fungi on your skin help train your immune system—but when that balance tips, chronic inflammation can follow. This new review reveals how and why. Study: Conversation between skin microbiota and the host: from early life to adulthood. Image Credit: Corona Borealis Studio / Shutterstock In a recent review published in … Read more
New research finds that kids who don’t eat enough calories face a higher risk of asthma — but piling on more food won’t keep cutting the risk. Here’s what parents and doctors need to know. Study: The relationship between energy intake and asthma in Americans aged 1–18 years: a cross-sectional study. Image Credit: OnlyZoia / Shutterstock In a … Read more