TOPLINE: In patients with locally advanced rectal cancer who receive neoadjuvant therapy, radiation dose intensification improves pathologic complete response but leads to a small increase in acute toxicities. METHODOLOGY: Preoperative radiochemotherapy is standard of care for treating locally advanced rectal cancer, but 20%-30% of the patients develop metastatic disease. Although radiation dose escalation has been … Read more
TOPLINE: Patients with clinically node-negative breast cancer after neoadjuvant chemotherapy demonstrated low axillary and locoregional recurrence rates after sentinel lymph node biopsy (SLNB) or targeted axillary dissection. METHODOLOGY: More conservative treatment options for women with node-positive breast cancer include SLNB and targeted axillary dissection. However, data comparing patient outcomes after targeted axillary dissection and SLNB … Read more
The treatment landscape for melanoma saw significant advancements in 2024, as highlighted by Elisa Funck-Brentano, MD, PhD, from Ambroise-Paré Hospital in Paris, France, during her presentation at the 2024 Dermatology Days of Paris conference in Paris. Checkpoint Inhibitors in Neoadjuvant Therapy The standard approach for treating resectable stage III melanoma with locoregional metastases has traditionally … Read more