Parasites trigger epithelial cell crosstalk to drive gut–brain signalling

Mice All experimental procedures were conducted in accordance with guidelines approved by the Institutional Animal Care Committees at the University of California, San Francisco (UCSF) and the South Australian Health and Medical Research Institute (SAHMRI) and aligned with the NIH and NHMRC Guide for the Care and Use of Laboratory Animals, respectively. Mice of both … Read more

Molecular signature of sleeping nociceptors offers new pain targets

Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors-a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain. … Read more

Insulin resistance in the brain may link Alzheimer’s and epilepsy

Researchers at the University of São Paulo (USP) in Brazil have succeeded in showing, in an animal model, that the process of insulin resistance in the brain affects both Alzheimer’s disease and epilepsy and may be a linking factor between the two diseases. The work, supported by FAPESP, confirms clinical evidence that people with epilepsy … Read more