TOPLINE: Administration of dexmedetomidine in patients undergoing cardiac surgery reduced the incidence of postoperative delirium by 38% but was associated with an increased risk for hypotension. METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 18 randomized controlled trials involving 3904 patients undergoing any type of cardiac surgery. They compared the use of dexmedetomidine with … Read more
TOPLINE: Patients with type 2 diabetes (T2D) who received glucagon-like peptide 1 (GLP-1) receptor agonists had a significantly lower risk of developing local or systemic complications — even if they developed acute pancreatitis — and showed more than a 50% reduction in risk for all-cause mortality than those who did not receive these medications. METHODOLOGY: … Read more
TOPLINE: Pentoxifylline, an anti–tumor necrosis factor alpha agent, did not improve survival outcomes in patients with severe alcohol-associated hepatitis complicated by acute kidney injury (AKI). METHODOLOGY: Severe alcohol-associated hepatitis is a life-threatening condition with corticosteroid treatment as the only therapy demonstrating short-term benefits, leading to the investigation of potential alternative therapies, such as pentoxifylline, particularly … Read more
TOPLINE: A substantial proportion of patients admitted to hospitals in Italy experienced acute kidney injury (AKI), which was associated with worsened in-hospital mortality outcomes, longer hospital stays, and more frequent admissions to intensive care units (ICUs). METHODOLOGY: Researchers conducted a retrospective observational study to examine the incidence of AKI in two Italian university hospitals from … Read more