Ribosome

New peptide antibiotic stops bacteria by binding where no drug has before

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Lariocidin hits drug-resistant bacteria where others fail — by hijacking the ribosome at a new site, bypassing defences, and opening the door to a new generation of antibiotics. Lariocidin, a lasso-shaped peptide with promising antibiotic properties. (Graphic: Dmitrii Travin and Yury Polikanov). Research: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome Researchers at McMaster University, … Read more

A versatile toolbox sets gold standard for characterizing IRES activity in cells

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Only recently has the ribosome – one of the oldest molecular machines in evolutionary terms – been recognized as an active regulator of gene expression at the level of protein biosynthesis. This is an important process for the development and function of cells, in which genetic information is converted into proteins. The final step, in … Read more