Pharmacology

Viagra ingredient improves symptoms in patients with Leigh syndrome

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Sildenafil – an active ingredient also marketed under the name of Viagra – improves symptoms in patients with Leigh syndrome. This has now been reported in the Cell journal by researchers at Charité – Universitätsmedizin Berlin, together with teams from Heinrich Heine University Düsseldorf (HHU), University Hospital Düsseldorf (UKD), and the Fraunhofer Institute for Translational Medicine … Read more

Scientists discover how herpes simplex virus softens cells to multiply faster

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Herpes simplex virus partially liquifies the tightly packed, gel-like interior of human cell nuclei to copy itself faster, a new study shows. The research centers on how the nucleus of each human cell houses the genetic machinery used to copy DNA-encoded instructions when it divides and multiplies as part of growth. Viruses invade human cells … Read more

Mussel-inspired adhesive prevents organ rejection

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A new technology has been developed to suppress immune rejection, the biggest challenge in organ transplantation, without causing systemic side effects. A research team from Pohang University of Science and Technology (POSTECH) and Ewha Womans University has developed the “Immune-Shield” technology, which directly sprays immunosuppressants onto the surface of organs using mussel-derived adhesive protein. These … Read more

Common cardio drugs proven safe in myeloma patients

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Commonly prescribed cardiovascular medications—such as statins, diuretics, and blood pressure drugs—appear to have little or no negative impact on survival among people living with multiple myeloma, according to new international research. The study, published in Scientific Reports, reflects a collaboration among scientists and oncologists in the United States, Australia, Qatar, and the United Arab Emirates … Read more

Comparing denture cleansers for effectiveness against Candida biofilms

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Background and objectives Candida species, particularly Candida albicans, are major contributors to denture-induced stomatitis because of their ability to form biofilms on removable dental prostheses. Although chemical cleansers are effective, concerns regarding material degradation and mucosal irritation have spurred interest in non-chemical alternatives. This review aims to systematically compare the efficacy of chemical and non-chemical denture cleansers … Read more

Grant supports research into how microglia may spread toxic tau in Alzheimer’s

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A researcher with the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio has received a two-year, $402,500 grant award from the Cure Alzheimer’s Fund to study how microglia, the brain’s resident immune cells, paradoxically might contribute to the spread of toxic forms of tau protein in the disease. Sarah C. … Read more

Mounjaro ingredient shows promise in lowering alcohol consumption

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For the first time, researchers show that tirzepatide – the active ingredient in the diabetes and weight-loss drug Mounjaro – reduces alcohol intake as well as relapse-like behaviors in rats and mice. The findings are considered relevant in the search for new treatments for alcohol use disorder. Researchers at the University of Gothenburg have previously … Read more

RNA micelles enable targeted chemotherapy without immune toxicity

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A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects. Researchers constructed tiny molecular clusters called RNA micelles, loaded them with potent chemo drugs and an … Read more

Understanding tumor growth patterns helps guide treatment after lung cancer

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When lung cancer treatment stops working, what happens next? New research reveals the answer may depend on how the cancer grows. Medical researchers at Flinders University have uncovered an important clue that could help doctors better predict what happens next for people with advanced lung cancer when their first treatment fails. Researchers looked at thousands … Read more