Wilms tumor found to contain millions of genetic changes

Researchers have uncovered that some childhood cancers have a substantially higher number of DNA changes than previously thought, changing the way we view children’s tumors and possibly opening up new or repurposed treatment options. Concentrating on a type of childhood kidney cancer, known as Wilms tumor, an international team genetically sequenced multiple tumors at a … Read more

USPSTF urges universal syphilis screening in pregnancy to prevent congenital infections

With congenital syphilis at a 30-year high in the US, experts stress that early and universal syphilis screening in pregnancy is vital to protect both mothers and newborns from preventable harm. Study: Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation Statement. Image Credit: Summit Art Creations / Shutterstock.com In a recent … Read more

Maternal testosterone levels shape boys’ activity and girls’ strength by age 7

New research links maternal PCOS and testosterone to reduced weekend activity in boys and weaker grip strength in girls, highlighting the lasting impact of in-utero hormone exposure on children’s physical development. Image Credit: Marta Design / Shutterstock Boys born to mothers who have polycystic ovary syndrome (PCOS) or who have higher levels of testosterone during the third … Read more

Uterine Cancer Survival Varies Widely by Race Across US

TOPLINE: A study of 162,500 patients with uterine cancer found that survival rates varied significantly by race and geographic location, with Black patients experiencing the worst survival outcomes in areas with high and low overall diversity. METHODOLOGY: Despite known racial and ethnic disparities in uterine cancer survival in the United States, data on the association … Read more

Discontinuing Oxytocin in Active Labor Reduces Cesarean Risk

TOPLINE: Discontinuing oxytocin during active labor was associated with a 20% lower risk for cesarean delivery and reduced the risk for uterine tachysystole and non-reassuring fetal heart rate tracings. The approach extends labor duration by approximately 30 minutes but shows potential benefits for delivery outcomes. METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 15 … Read more

Uterine Rupture Risk Rises in Modern TOLAC Cases

TOPLINE:  National rates of uterine rupture in trial of labor after cesarean (TOLAC) increased from 0.20% in 2010 to 0.37% in 2022, with an annual percentage increase of 6.2%. Among 1,016,073 deliveries analyzed, 2888 uterine ruptures occurred, representing 0.28% of cases. METHODOLOGY: Researchers conducted a repeated cross-sectional analysis using natality files from the National Vital … Read more

Gynecological conditions may raise risk of heart disease and stroke

Having one or more common gynecological disorders, such as endometriosis or heavy or irregular periods, may be linked to a heightened risk of heart disease and conditions that affect blood flow to the brain (cerebrovascular disease), finds a pooled data analysis of the available evidence published online in the journal Heart. Although the quality of the … Read more

Study explores how nanoplastics could affect child’s immune system during pregnancy

Allergies and asthma are widespread diseases that could arise during embryonal development in the womb. A team led by Empa researcher Tina Bürki is investigating the possible causes of this. The focus is on nanoplastic particles, which could lead to the development of a hypersensitive immune system in the child. The project is supported by … Read more