New research reveals how fluoxetine boosts immune protection and prevents sepsis-related heart and metabolic damage.
Study: Fluoxetine promotes IL-10–dependent metabolic defenses to protect from sepsis-induced lethality. Image Credit: luchschenF/Shutterstock.com
In a recent study published in Science Advances, researchers showed that fluoxetine, a selective serotonin reuptake inhibitor (SSRI), promotes metabolic defenses to protect from sepsis-induced death.
Background
Sepsis is a life-threatening condition caused by a dysregulated response to infection. Several trials have been performed to target pro-inflammatory cytokines using neutralizing antibodies, albeit they achieved little success.
Possible reasons for the poor success of this strategy are that it renders patients immunocompromised,…