Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of later tumour growth, offering a new mechanistic link between chronic inflammatory disease and cancer risk. Study: Epigenetic memory of colitis promotes tumour growth. Image Credit: Antonio Marca / Shutterstock In a recent study published in the journal Nature, … Read more
Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). What makes our body turn against itself? Failure of the immune system to distinguish ‘self’ from ‘non-self’ entities leads to excessive autoimmune responses against self-proteins like myelin, which forms … Read more
New research published in Nature Cardiovascular Research reveals that heart failure and atrial fibrillation share underlying genetic and molecular mechanisms, suggesting that the two cardiovascular conditions may be less distinct than previously thought. Two serious heart conditions that often coexist Heart failure occurs when the heart muscle is damaged and unable to pump enough nutrient-rich blood to meet the … Read more
A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more
Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells – key cells lining the liver’s tiny blood vessels. The long-term stasis of blood in the liver, known as chronic liver congestion, can lead to a range of … Read more
Scientists at Gladstone Institutes have flipped the traditional approach to finding potential treatments for deadly diseases. Instead of starting with a disease and hunting for a cure, they began with vitamins and systematically identified genetic diseases that could benefit from high-dose supplements. Using this framework, the team discovered that vitamin B3 supplementation, when tested in … Read more
New research shows that Rytvela, an anti-inflammatory drug candidate, decreased premature birth and infant mortality when administered after the onset of preterm labor in a preclinical mouse model. The current standard treatment for preterm labor, Nifedipine, failed to confer similar benefits. Addressing an unmet medical need, Rytvela represents a promising treatment approach to safely … Read more
New research reveals how hypoxia-driven red blood cell adaptations may reshape glucose regulation, offering fresh insight into diabetes biology and potential therapeutic strategies. Study: Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude. Image Credit: nobeastsofierce / Shutterstock In a recent study published in the journal Cell Metabolism, researchers investigated … Read more
Researchers at Oregon State University have developed and tested in a mouse model a new type of nanoparticle that enables the removal of melanoma tumors with a low-power laser. After the systemically administered nanoparticles accumulate in cancerous tissue, exposure to near-infrared light causes them to heat up and destroy the melanoma cells, leaving healthy tissue … Read more
A retrievable immune scaffold reveals a 5–7 week presymptomatic window for tracking type 1 diabetes progression, long before blood sugar tests turn positive. Study: Longitudinal monitoring of type 1 diabetes progression to disease onset. Image credit: Halfpoint/Shutterstock.com A recent study published in Science Advances described the application of subcutaneous microporous scaffolds, viz., immunological niches (INs), for … Read more