Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis. This review by Gareev et al. focuses on immune-derived microRNAs (immuno-miRs) as pivotal modulators of immune responses in cardiovascular settings, highlighting their roles in pathophysiology, diagnostic potential, and therapeutic promise.
Introduction
The authors introduce CVDs as a global health crisis, exacerbated by the interplay between immune dysregulation and cardiovascular remodeling. Immune cells like macrophages and T cells, while crucial for homeostasis, can trigger chronic inflammation, fibrosis, and plaque instability when misregulated. Recent discoveries spotlight miRNAs,…