Study reveals how extracellular matrix stiffness regulates breast cancer metastasis

A study by researchers at the University of California San Diego could make it easier to treat breast cancer by uncovering a new way the body helps prevent its spread. The scientists discovered a new role for an inflammatory protein called TYK2 in mechanotransduction, the process by which cells sense and respond to their physical … Read more

Study explores if wastewater can track colorectal cancer at population level

Researchers demonstrate that colorectal cancer–associated RNA biomarkers, including CDH1, can be detected in community wastewater using a proof-of-concept approach. Study: Using wastewater for population-level colorectal cancer surveillance: a future research agenda. Image Credit: Siyanight / Shutterstock A proof-of-concept feasibility study published in the Journal of Epidemiology & Community Health reveals a feasibility-based approach to detecting colorectal … Read more

Soluble E-cadherin drives brain metastasis in aggressive inflammatory breast cancer

Researchers at The University of Texas MD Anderson Cancer Center have identified a targetable driver of brain metastases in patients with aggressive inflammatory breast cancer. The study uncovers a novel role for soluble E-cadherin (sEcad) in promoting tumor invasion while resisting cancer cell death and triggering brain inflammation via the CXCR2 signaling pathway. The results … Read more