Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of later tumour growth, offering a new mechanistic link between chronic inflammatory disease and cancer risk. Study: Epigenetic memory of colitis promotes tumour growth. Image Credit: Antonio Marca / Shutterstock In a recent study published in the journal Nature, … Read more
In the months before his wedding, Queens resident Roberto Pineda Sanchez noticed persistent rectal bleeding, a dangerous symptom he almost ignored. Thankfully, he decided to bring it up to his doctor—a potentially lifesaving choice that led to his swift and successful treatment for colorectal cancer. “He said it’s probably a hemorrhoid or fissure or something … Read more
Chronic inflammation can raise a person’s risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk. Scientists at the Broad Institute and Harvard University have revealed in mice that after colitis, or chronic intestinal inflammation, seemingly healed … Read more
Research published in The Lancet Gastroenterology & Hepatology provides robust evidence for the use of a digital visualization and decision support tool in colorectal (bowel) surgery. This is the first time that a digital decision support tool has been conclusively proven to significantly improve outcomes in this type of surgery. Colorectal cancer is the third … Read more
Researchers demonstrate that colorectal cancer–associated RNA biomarkers, including CDH1, can be detected in community wastewater using a proof-of-concept approach. Study: Using wastewater for population-level colorectal cancer surveillance: a future research agenda. Image Credit: Siyanight / Shutterstock A proof-of-concept feasibility study published in the Journal of Epidemiology & Community Health reveals a feasibility-based approach to detecting colorectal … Read more
Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to metastasis and limited responses to immunotherapy in most patients. Although immune checkpoint inhibitors have transformed treatment for certain tumor subtypes, the majority of colorectal cancers remain “immune-cold,” meaning they fail to trigger effective anti-tumor immunity. Increasing evidence suggests that tumor-associated … Read more
A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer … Read more
A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC). The research, conducted by an international team of scientists from institutions including Sun Yat-sen University and The Chinese University of Hong Kong, identified the RNA N⁶-methyladenosine (m⁶A) reader insulin-like growth factor 2 mRNA-binding … Read more
Baylor University researchers have published a novel approach to fight colorectal cancer, using modified bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. Michael S. VanNieuwenhze, PhD, FRSC, University Distinguished Professor and chair of the Department of Biology, along with Baylor doctoral students and a colleague at Texas Tech University Health Sciences … Read more
A novel approach to improving survival in treatment-resistant Cancers News-Medical Source link